Pearland is largely located in northern Brazoria County south of Houston, with portions of the city extend north into Harris County and west into Fort Bend County. Affordable housing, outstanding schools, safe neighborhoods and superb quality of life has led to tremendous growth in Pearland. It is the third-largest city in the Houston MSA, and from 2000 to 2010, ranked as the fastest-growing city in the Houston MSA and the second-fastest-growing city in Texas.

Close proximity to Houston, just a short 20-minute drive to downtown, allows residents and businesses to experience all the city has to offer including professional sports, world-class cultural amenities and recreation. Pearland's labor force and job base grew substantially with its population growth. The city’s workforce and community amenities have made Pearland an attractive location for large medical-related companies seeking new quarters. Other employers in the area include retail, manufacturing, energy, and business and professional services.