The Texas Medical Center (TMC) is a 2.1-square-mile medical district and neighborhood in south-central Houston, Texas. By square footage it’s the eight largest business district in the nation. Over sixty medical institutions, largely concentrated in a triangular area between Brays Bayou, Rice University, and Hermann Park, are members of the Texas Medical Center Corporation—a non-profit umbrella organization—which constitutes the largest medical complex in the world.

TMC has an extremely high density of clinical facilities for patient care, basic science, and translational research. TMC is serviced by the METRORail Red Line which connects the district to Downtown Houston and NRG Park along the city's Innovation Corridor.