Twenty–seven Fortune 500 companies are headquartered in the Houston region. Houston ranks second among U.S. metro areas for most Fortune 500 headquarters.

• Twenty-seven companies on the 2026 Fortune 500 list are headquartered in the Houston metro area, ranking Houston second in the country behind New York (62) and tied with Chicago (27), while being ahead of Dallas-Fort Worth (24).
• Expand Energy (#362) announced it is moving headquarters from Oklahoma to Spring, TX in 2026. When the Expand Energy move is complete, Houston will undisputedly rank No. 2 with 28 Fortune 500 companies.
• The biggest movers among Houston-based companies on the Fortune 500 between ’25 to ’26 are Cheniere Energy (moved to #223 from #275), Westlake (dropped to #388 from #345), and Par Pacific Holdings (dropped to #502 from #474).